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Biopsy : In this slightly thicker cut of the biopsy, cytoplasmic margins of the myeloma cells are no easier to define. Whether the cut is thick or thin, when cells are tightly packed, the familiar outline of plasmacytoid cells with eccentric nuclei may be difficult to discern. See comment.
In tightly packed marrows, it is often easier to detect familiar plasmacytoid outlines in areas where sheets of the cells have become fractured during sectioning or frayed at biopsy margins. Separation of cells may then facilitate characterization of cells as plasmacytoid. One other feature of the current frame is the relative ease with which lymphoid cells are identified – particularly in the left third of the field. Dutcher bodies are also easily identified. By sheer serendipity, the nucleus of a fat cell is observed in the RLQ.